Critical ADME PK services
PHYSICOCHEMICAL PROFILING
Inappropriate physicochemical properties may result in poor bioavailability. Unacceptable pharmacokinetics, or unexpected safety problems in turn may lead to failures in drug discovery. Incorporation of physicochemical characterization of lead compounds early in drug discovery is essential for successful drug discovery.
Solubility, lipophilicity and stability are among the most fundamental physicochemical properties of drug candidates, and their in vitro measurements are important to evaluate drug-like property.