BIOANALYSIS AND PK SERVICES

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Pharmacokinetics is the study of drug absorption, distribution, metabolism and elimination (ADME) in animal and human body. Many different routes of administration (e.g., oral, intravenous, subcutaneous, intramuscular, topical, sublingual and ocular administration) can be done. 

Typically, the first In vivo experiment during an oral drug discovery project would be a single oral and IV bolus dose in a preclinical species. IV dose already allow the determination of key PK parameters such as AUC, Cmax, t½, Vss and clearance. Oral PK, in combination with the IV data allows the determination of oral bioavailability (F). Low oral F can be caused by poor absorption and/or high first-pass hepatic elimination. Collection of urine or bile allows calculation of renal and biliary clearance and identification of metabolites.

At Cytovier, we offer Non-GLP PK and bioanalysis services using LC/MS/MS. Bio analysis of In vitro, in vivo assay samples and PK samples in any matrix can be performed with quality data outcome every time.

We offer an extensive range of preclinical animal models for drug discovery and development, through access to preferred provider.